Synthesis, Spectroscopic Studies and Antimicrobial Activity of Novel Aromatic Hydrazones Derived from 1-Hydralazinophthalazine

Aims: To synthesize novel Schiff bases, determine their structures by spectroscopic methods including IR, 1H and 13C NMR, single crystal X-ray diffraction and elemental analysis and test them against some selected bacterial strains.

Methodology: 1-Hydralazinophthalazine was condensed with 5-methylfurfural and 2-acetylthiophene to form hydrazones. The Schiff bases obtained were screened for antimicrobial activity using the agar-diffusion method.

Results: The spectroscopic data indicate the presence an exocyclic C=N and an N-H bond on the hydralazine moiety of the Schiff base. These compounds show moderate activity against the selected bacterial strains

Conclusion: Two new Schiff bases were derived from hydralazine hydrochloride and their structures were determined by elemental analysis, single X-ray diffraction method, IR and NMR. These compounds showed moderate antimicrobial activity against some selected bacterial strains compared to amoxicillin and norfloxacin as standards.