Wang, Shuo and Chen, Jie and Li, Liangchun (2016) Study on the Synthesis of 2,6-di(pyridin-2-yl)pyridin- 4(1H)-one. International Research Journal of Pure and Applied Chemistry, 11 (4). pp. 1-6. ISSN 22313443
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Abstract
In this paper, 2,6-di(pyridin-2-yl)pyridin-4(1H)-one was synthesized from ethyl picolinate and acetone via Kröhnke-type reaction. Initially, optimization of the reaction conditions for the synthesis of 1,5-bis(2′-bipyridyl)pentane-1,3,5-trione 2, such as the molar ratio of ethyl picolinate: acetone: sodium hydride and the reaction temperature, were researched. In the ring-forming step, the different nitrogen sources were also researched. At the end, the optimal reaction conditions obtained: the best reaction temperature of first step is 10°C, the molar ratio of ethyl picolinate: acetone is 2:1.1, and ethyl picolinate: sodium hydride is 2: 3, and the optimum nitrogen source is ammonium formate. Under the optimal reaction conditions, the total yield is obtained up to 66% (the yield is only 37% refer to the literatures).
Item Type: | Article |
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Subjects: | Research Asian Plos > Chemical Science |
Depositing User: | Unnamed user with email support@research.asianplos.com |
Date Deposited: | 15 Jun 2023 12:30 |
Last Modified: | 10 Jan 2024 04:20 |
URI: | http://archiv.manuscptsubs.com/id/eprint/868 |