POLYACRYLAMIDE-ALGINATE COATED HYDROGEL BEADS AS PROTEIN DELIVERY SYSTEM#

To prevent a rapid drug release from alginate beads in simulated intestinal media, alginate beads were coated by polycations polymer. Polyacrylamide (PAM) was selected and evaluated as coating material for controlling the release of BSA as protein drug model for the first time. This study focused on the release behaviour of BSA from polycations-coated alginate beads. Effect of coating alginate beads both in the wet or dry state on the release behaviour was discussed. It was found that as the coating time increase, the BSA release generally decreased. The suitable kinetics model for the release of BSA has been established and the kinetics parameters were calculated. The release order of BSA has been changed from first order in case of un-coated beads to zero order as a result of the coating process using Polyacrylamide.