THE ANTIOXIDANT DRUG “U-74389G” ATTENUATES THE MEAN CORPUSCULAR HEMOGLOBIN CONCENTRATION LEVELS DURING HYPOXIA REOXYGENATION INJURY IN RATS

Background: The effect of the antioxidant drug “U-74389G” was examined on a rat model and particularly in an hypoxia - reoxygenation protocol. The effects of that molecule were studied hematologically using blood mean corpuscular hemoglobin concentration (MCHC) levels.

Methods: 40 rats of mean weight 231.87 g were used in the study. MCHC levels were measured at 60 min of reoxygenation (for groups A and C) and at 120 min of reoxygenation (for groups B and D). The drug U-74389G was administered only in groups C and D.

Results: U-74389G administration non-significantly decreased the MCHC levels by 0.95%±0.63% (p=0.11). Reoxygenation time non-significantly decreased the MCHC levels by 0.53%±0.64% (p=0.39). However, U-74389G administration and reoxygenation time together non-significantly decreased the MCHC levels by 0.69%±0.37% (P= 0.06).

Conclusions: Findings from this study suggest that U-74389G administration, reoxygenation time and their interaction have no effect on MCHC values. Although MCHC is a sensitive hematologic index; the result was not clinically important.