PHYTOMOLECULES OF Commiphora wightii DISPLAY POSITIVE AFFINITY FOR DEHYDROGENASE OF Commiphora wightii: POSSIBLE PREVENTIVE AND THERAPEUTIC USAGE IN SKIN DISEASE

Skin disease is caused by Staphylococcus sp. One of the key enzymes involved in its biochemical pathway is dehydrogenase Plant extract of Commiphora wightii can be effectively used against skin disease. The molecular docking of the phytochemicals with the enzyme was studied using Biovia Discovery Studio. Molecular docking-based screening of a few phytochemicals revealed that the phytochemicals effectively associate with the active site of the protein and hence bears diagnostic and therapeutic potentials skin disease. Phytochemicals including α-pinene and eugenol may effectively deactivate the dehydrogenase enzyme thereby interrupting the life cycle of Staphylococcus.